The answer is simple - you will lose absolutely no muscle size during time off if you train primarily for strength in the gym. If you haven’t yet switched over to a lower volume routine based around getting stronger and optimizing progressive overload, then yes - you will lose quite a bit of muscle size.
This happens to a lot of guys who train 4, 5, 6 days a week.. they take a few days off to travel and they end up losing all of their hard work! Training for strength on a lower volume routine 2-4 times a week builds the muscle that is there to last, the muscle that’s lasts even if you do take some time off.
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